J Am Acad Dermatol. 2019 Feb 4. Epub 2019 Feb 4. PMID: 30731173
Coffee, tea, caffeine, and risk of non-melanoma skin cancer in a Chinese population: The Singapore Chinese Health Study.
BACKGROUND: While epidemiological studies in populations of European-descent suggest possible chemo-protective effect of caffeine against non-melanoma skin cancer (NMSC), data in Asian populations are lacking.OBJECTIVES: We examined the relations between coffee, tea and caffeine consumption, and NMSC risk among Chinese in Singapore.METHODS: We used data from the Singapore Chinese Health Study, a prospective cohort of 63,257 men and women aged 45-74 years at recruitment from 1993 to 1998. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using multivariable Cox proportional hazard models.RESULTS: Coffee drinking was associated with reduced NMSC risk in a dose-dependent manner (P trend