Front Microbiol. 2019 ;10:299. Epub 2019 Feb 20. PMID: 30842764
ZS2058 andGG Use Different Mechanisms to PreventInfection.
Pathogen-induced infectious diseases pose great threats to public health. Accordingly, many studies have investigated effective strategies targeting pathogenic infections. We previously reported the preventive effects ofZS2058 (ZS2058) andGG (LGG) againstspp. in a murine model. Here, we compared the mechanisms underlying the preventive effects of thesestrains. Notably, reduced C-reactive protein levels were observed with both ZS2058 and LGG, which suggests abrogated anti-infection and inflammatory responses. ZS2058 more efficiently reduced the pathogenicity ofby increasing the level of propionic acid in feces and production of mucin 2 in the mouse colon and activity through the interleukin (IL)-23/IL-22 and IL-23/IL-17 pathways. Meanwhile, LGG more strongly alleviated gut inflammation, as indicated by changes in the levels of tissue necrosis factor (TNF)-α, IL-10 and myeloperoxidase (MPO) in infected mice. Moreover, both ZS2058 and LGG restored the levels of interferon (INF)-γ, a cytokine suppressed by, albeit through different pathways. Our results demonstrate that ZS2058 and LGG preventinfection via different mechanisms.