Int J Mol Sci. 2019 Mar 5 ;20(5). Epub 2019 Mar 5. PMID: 30841568
Intake of Red and Processed Meat, Use of Non-Steroid Anti-Inflammatory Drugs, Genetic Variants and Risk of Colorectal Cancer: A Prospective Study of the Danish"Diet, Cancer and Health"Cohort.
Red and processed meat have been associated with increased risk of colorectal cancer (CRC), whereas long-term use of non-steroid anti-inflammatory drugs (NSAIDs) may reduce the risk. The aim was to investigate potential interactions between meat intake, NSAID use, and gene variants in fatty acid metabolism and NSAID pathways in relation to the risk of CRC. A nested case-cohort study of 1038 CRC cases and 1857 randomly selected participants from the Danish prospective"Diet, Cancer and Health"study encompassing 57,053 persons was performed using the Cox proportional hazard model. Gene variants in,,,,,,,,, andwere investigated.rs6983267 was associated with the risk of CRC per se (