Curr Pharm Des. 2019 Jul 22. Epub 2019 Jul 22. PMID: 31333118
Wogonin alleviates hyperglycemia through increased glucose entry into cells via AKT/GLUT4 pathway.
Insulin resistance and type 2 Diabetes mellitus resulting in chronic hyperglycemia is a major health problem in the today modern world. Many drugs have been tested to control hyperglycemia which is believed to be main factor behind many of the diabetes related late term complications. Wogonin is a famous herbal medicine which has been shown to be effective in controlling diabetes and its complications. In our previous work we have shown that wogonin is beneficial in many ways in controlling diabetic cardiomyopathy. In this review, we have mainly explained wogonin anti-hyperglycemic property through AKT/GLUT4 pathway. Here we briefly discussed that wogonin increases Glut4 trafficking to plasma membrane which allow increased entry of glucose and thus alleviate hyperglycemia. Conclusion: Wogonin can be used as anti-diabetic and anti-hyperglycemic drug and works via AKT/GLUT4 pathway.