Infect Drug Resist. 2019 ;12:2251-2257. Epub 2019 Jul 22. PMID: 31413602
Association between vitamin D and latent tuberculosis infection in the United States: NHANES, 2011-2012.
Background: Latent tuberculosis infection (LTBI) is a precursor of active tuberculosis diseases and an important issue in the United States and worldwide. The association between vitamin D deficiency and LTBI is poorly understood.Methods: From 2011 to 2012, the National Health and Nutrition Examination Survey (NHANES) assessed LTBI (according to tuberculin skin testing and QuantiFERON-TB Gold In-Tube) and measured serum levels of vitamin D. We evaluated the association between LTBI and vitamin D using multivariate logistic regression models adjusted for known confounders.Results: The LTBI group had a lower 25-hydroxyvitamin D [25(OH)D] level than the non-LTBI group (=0.0012). The adjusted risk of LTBI was significantly higher among participants with serum 25(OH)D levels