Chemosphere. 2019 Dec 2 ;244:125527. Epub 2019 Dec 2. PMID: 31816550
Developmental exposure to Pbinduces transgenerational changes to zebrafish brain transcriptome.
Lead (Pb) is a major public health hazard for urban children, with profound and well-characterized developmental and behavioral implications across the lifespan. The ability of early Pbexposure to induce epigenetic changes is well-established, suggesting that Pb-induced neurobehavioral deficits may be heritable across generations. Understanding the long-term and multigenerational repercussions of lead exposure is crucial for clarifying both the genotypic alterations behind these behavioral outcomes and the potential mechanism of heritability. To study this, zebrafish (Danio rerio) embryos (