Fermented barley bran water-soluble extracts inhibit the expression of adipogenic and lipogenic regulators in 3T3-L1 adipocytes.

Fermented barley bran water-soluble extracts inhibit the expression of adipogenic and lipogenic regulators in 3T3-L1 adipocytes.

PMID: 

Food Sci Biotechnol. 2016 ;25(6):1727-1735. Epub 2016 Dec 31. PMID: 30263468

Abstract Title: 

(fermented barley bran) water-soluble extracts inhibit the expression of adipogenic and lipogenic regulators in 3T3-L1 adipocytes.

Abstract: 

prepared from fermented barley bran is a traditional fermented food found only in the Gyeongsang-do area of South Korea. There have been no studies reported to date despite the potential bioactivities of. In this study, the anti-obesity activities ofextracts (SEs) during 3T3-L1 differentiation into adipocytes were investigated. SEs inhibited adipocyte differentiation by suppressing the CCAAT/enhancer binding protein-β and sterol regulatory element binding protein-1c expression in the early stage of differentiation, followed by the suppression of the peroxisome proliferator-activated receptor-γ, CCAAT/enhancer binding protein-α, and adiponectin. These changes in adipogenic markers induced inhibition of lipogenesis via down-regulation of mainly fatty acid synthase, acetyl-CoA carboxylase, fatty acid binding protein 4, and perilipin. These results were more significant in the extract offermented with isolatedMFST compared to naturally fermentedgroup. SEs can be considered as a useful material for developing food with health benefits and anti-obesity properties.

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