Phytother Res. 2020 Mar 17. Epub 2020 Mar 17. PMID: 32182635
Dietary citrus and/or its extracts intake contributed to weight control: Evidence from a systematic review and meta-analysis of 13 randomized clinical trials.
Randomized controlled trials, being published in English and investigating the associations of at least 4 weeks intervention of citrus and/or its extracts on weight loss among adults, were searched from PubMed, Web of Science, Scopus, and Cochrane by June 2019 to conduct a meta-analysis. Thirteen articles, including 921 participants, were selected and evaluated by modified Jadad scale. Pooled resultsby the random-effects model showed that citrus and/or its extracts administration significantly reduced 1.280 kg body weight (95% CI: -1.818 to -0.741, p = 0.000, I= 81.4%), 0.322 kg/mBMI (95% CI: -0.599 to -0.046, p = 0.022, I= 87.0%), 2.185 cm WC (95% CI: -3.804 to -0.566, p = 0.008, I= 98.3%), and 2.137 cm HC (95% CI: -3.775 to -0.500, p = 0.011, I= 96.2%), respectively, but no significantly decreased effects on WHR and body fat were observed. Subgroup analysis deduced the different effects of study location, intervention duration on body weight associated indices. No publication bias was observed. Our meta-analysis supported the beneficial effects of citrus and/or its extracts supplement on body weight control, and future well-designed studies are required to firmly establish the clinical efficacy of citrus and/or its extracts intervention on body weight.